At the end of 1-month therapy, the alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatin kinase (CK) levels of one patient in the atorvastatin 80 group, increased to three-fold to upper normal limits. The dosage range of LIPITOR is 10 to 80 mg once daily. ; Analysis and/or interpretation A.T., M.S.A., E.C.K., M.U.Y., N.A., K.D. expand_more. Adipocytes as regulators of energy balance and glucose homeostasis. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. A medication error is defined as any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the healthcare professional, patient, or consumer, according to the National Coordinating Council for Medication Error Reporting and Prevention. Epub 2011 Oct 21. To the best of our knowledge, the present study is the first study that investigated and compared the effects of high-dose potent statins on the serum endocan levels. Conversely, robust evidence exists for atorvastatin 80 mg. Comparative effects of high-dose atorvastatin versus rosuvastatin on lipid parameters, oxidized low-density lipoprotein, and proprotein convertase subtilisin kexin 9 in acute coronary syndrome. No: BI-20022), Chemerin (BioVendor, Cat. Hope this helps reassure you. Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial. the contents by NLM or the National Institutes of Health. But in our study, atorvastatin 80 mg/day seems to have no effects on galectin-3 levels in patients with AMI at the end of 4-week therapy. Elevated Human Endothelial Cell-Specific Molecule-1 Level and Its Association With Coronary Artery Disease in Patients With Hypertension. Henderson NC, Mackinnon AC, Farnworth SL, Kipari T, Haslett C, Iredale JP, et al. Doctors diagnose high cholesterol through a simple blood test. If you are having trouble keeping multiple medications straight, ask your doctor or pharmacist about helpful aids. Last updated on Jun 9, 2023. Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, et al. National Library of Medicine Evidence from randomized trials of pravastatin, simvastatin, and atorvastatin for cardiovascular disease prevention. PMC Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Ganiats TG, Holmes DR, Jr, et al. Take atorvastatin exactly as directed. Levels of LDL-C were calculated by using the Friedewald formula. My history is mild MI in Feb this year, one Is anyone else taking 80mg of atorvastatin. official website and that any information you provide is encrypted High-intensity statin therapy yields better outcomes in acute coronary syndrome patients: a meta-analysis involving 26,497 patients. The elevated levels of the endocan in patients with tumor progression or in patients with sepsis suggest that endocan may be a probable biomarker for endothelial dysfunction or endothelial activation (7, 8). Thanks, interesting to get others views. Am J Ther. It is associated with obesity, metabolic syndrome, and inflammation. ; Data collection and/or processing A.T., B.., M.S.A., H.T., C.A., E.C.K., F.A. Are statins created equal? Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. How are you coping with it all? We designed and conducted a study to investigate and compare the effects of atorvastatin 80 mg and rosuvastatin 40 mg on the lipid profiles and the levels of endocan, chemerin, and galectin-3 in patients with AMI who underwent revascularization as a substudy of a previous article investigating the effects of atorvastatin 80 mg and rosuvastatin 40 mg on the plasma PCSK-9 . Anything out of the ordinary? I took them religiously for 9 years thinking this, maybe they did in my case too, but they didnt prevent my atherosclerosis progressing to the point that I needed a bypass. In our study, rosuvastatin 40 mg decreased the galectin-3 levels from 18.25 (12.8223.82) ng/mL to 16.60 (10.6020.15) ng/mL, and further studies are needed to clarify the association between the reduction of the galectin-3 levels with rosuvastatin 40 mg and long-term clinical endpoints. Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). Accessibility Is it safe to take 80 mg of atorvastatin? - Studybuff.com Comparison of atorvastatin 80 mg/day versus simvastatin 20 to 40 mg/day on frequency of cardiovascular events late (five years) after acute myocardial infarction (from the Incremental Decrease in End Points through Aggressive Lipid Lowering [IDEAL] trial) Am J Cardiol. eCollection 2021. The site is secure. It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body. The absolute and percentage changes of lipid parameters after 4-week therapy in both groups are listed in Table 3. No: MBS177114) were determined with the enzyme-linked immunosorbent assay technique. Types of stents (bare metal stent or drug eluting stent) and the number of revascularized vessels were also comparable among the two treatment groups (Table 1). Thank you, DakCB-UK, I'll bring this up with my doc, but I've only tried Simvastatin so far (40mg then 20mg) so I expect she'll prescribe other types of statin in order of ascending cost! 2 Simvastatin in particular is the most notable of the statins for this 3 but not exclusively; high-dose atorvastatin has similar problems. HHS Vulnerability Disclosure, Help Gullestad L, Ueland T, Kjekshus J, Nymo SH, Hulthe J, Muntendam P, et al. Clin Ther. The ratio of TC/HDL-C also showed remarkable reduction in both groups (p<0.001), (Table 2). Galectin-3 is a 26 kDa, soluble -galactoside-binding lectin, mainly secreted by macrophages and has effects on phagocytosis, apoptosis, cell growth/proliferation, and adhesion. Conclusion: My neighbour is a prime example of statin taking over 14 years. Everybody who had replied seems to be very happy to continue to take what I consider a very high dose of 80mg for long periods, perhaps for the rest of your life. Thank you very much for your reply. ALSO READ: What To Do If You Accidentally Took Double Dose of Carvedilol, you should drink of water per day. Previous studies showed that statins have some beneficial effects independent of the LDL reduction, which are called pleiotropic effects (34). To Relieve or eliminate the symptoms of the legs by treating the probable causes by: - shedding some weight. 2009 Dec 15;54(25):2358-62. doi: 10.1016/j.jacc.2009.10.005. Madrigal-Matute J, Lindholt JS, Fernandez-Garcia CE, Benito-Martin A, Burillo E, Zalba G, et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. Immunohistochemical analysis revealed that endocan is highly expressed in these plaques, and the authors hypothesized that endocan may contribute the neointimal formation process during atherosclerosis (6). Most common side effects of Lipitor are minor. The aim of this study is to investigate and compare the effects of high doses of atorvastatin and rosuvastatin on serum endocan, chemerin, and galectin-3 levels in patients with acute myocardial infarction (AMI). The MIRACL study looked at the effects of a high dose of Lipitor on 3086 patients in the hospital after angina or nonfatal MI and followed them for 16 weeks. FOIA Cholesterol (and triglycerides) are fats that are made in your body. Continuous variables were defined as meansstandard deviation or median (interquartile range), and categorical variables were given as percentages. However, the dose is usually not more than 80 mg per day. Galectin-3 predicts response to statin therapy in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA), http://www.who.int/mediacentre/factsheets/fs310/en/. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, et al. Krysiak et al. Thank you all for taking the time to reply to my post, I shall continue on 80mg as suggested by Doctor and it appears most of you are ok on that also , My husband is still on 80mg with cholesterol levels down to 3.1. eCollection 2022. Abstract Atorvastatin has been shown to reduce coronary events and revascularization procedures in patients with multiple risk factors for coronary heart disease. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. The present study suggests that atorvastatin 80 mg compares favourably to simvastatin in terms of efficacy and has a similar tolerability profile. PMC DISCLAIMER: The topics and articles published on this website including text, graphics, videos info graph and other material are for informational purposes only and should not be substituted for professional medical advice. Patients were similar between treatment groups: mostly men (62.9%), over 60 years old (68.1%), non-smokers (81.0%) taking statins for secondary prevention (56.9%). Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Myocardial infarction remains the leading cause of morbidity and mortality worldwide. There were no statistically significant differences between both treatment arms among the results of lipid parameters at the end of 1- month therapy except LDL-C levels. Careers, Unable to load your collection due to an error. My personal experiences is that I prefer to reduce or eliminate all medications if at all possible as all drugs have unwanted side effects. Ah thank you for your replies, this is very comforting and helpful to me, I am due an assessment /blood test soon but feel more reassured o continue on high dose now. Admission Endocan Level may be a Useful Predictor for In-Hospital Mortality and Coronary Severity Index in Patients With ST-Segment Elevation Myocardial Infarction. Aksan et al. Second, we could not show and compare the effects of these potent statins on other inflammatory markers such as hs-CRP, TNF-, IL-1, and IL-6. Partly due to fewer people smoking, not sure we can say diets have improved as diabetes and obesity are increasing so statins may well have their place. Fully agree, it is very much a dilemma which is why I continue to ask these questions. Good luck xx. 2022 Jun 28;2022:2751750. doi: 10.1155/2022/2751750. Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris. Dark urine? Clinicians face a conflict between prescribing for cost (simvastatin 80 mg) or for efficacy (atorvastatin 80 mg). Statin side effects: Weigh the benefits and risks - Mayo Clinic My GP told me this is fairly standard after a heart attack, but she was happy to reduce it to 40mg as I was rather stressed about the whole heart attack business and the statins were distressing me as much as anything else. The NICE management guidance that tells GPs to refer is not dependent on the total cholesterol level. Not sure if statins will be put back on 40mg now after the heart attack. Kundi et al. This site needs JavaScript to work properly. There were no significant differences between the two groups among the baseline levels of endocan, chemerin, and galectin-3 (Table 1). he has a permanently stiff neck and has been diagnosed with muscle wasting, he has come off them now but it is too late to rebuild/repair the damage, he is 68. hi im not sure about that test ive been to ent and they did the tests on me and said i didnt have vertigo i feel better not being on statins but my cardiac consultant wants me on them thanks for your advice god bless, thank you bigleg for your advice again god bless. MeSH Menon et al. The target range for us 'hearties' is 4.0 or below, although the LDL/HDL/etc. High Blood Sugar. Although our study is the first investigation that demonstrates the positive effects of rosuvastatin on the chemerin levels in patients with AMI, we think that there is a need for further large-scale studies. Rikitake Y, Kawashima S, Takeshita S, Yamashita T, Azumi H, Yasuhara M, et al. Certainly I no longer have the side effects which to me seems to out-way the very small absolute risk reduction which Statins actually provide. The .gov means its official. This should minimise the risk of restenosis. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. 1]. A total of 116 patients had taken simvastatin 80 mg or atorvastatin 80 mg. 2014 AHA/ACC Guideline for the Management of Patients With Non-ST-Elevation Acute Coronary Syndromes:Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis. Am Heart J. The 80-mg dose should not be used in new patients or those taking lower doses of the drug who need to lower their cholesterol further, the agency said in a safety alert, which outlined label changes and dose limitations for the drug. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. ; Literature search A.T., B.., C.A. Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasiela WJ, Tsai J, et al. A systematic review and meta-analysis on the therapeutic equivalence of statins. Endothelial Cell Specific Molecule-1 (ESM-1), a Novel Secreted Proteoglycan Stimulates Vascular Smooth Muscle Cell Proliferation and Migration. The aim of this audit was to examine the use, efficacy and tolerability of high intensity statin treatment (simvastatin 80 mg; atorvastatin 80 mg) in primary care. Lipitor Print Save Lipitor Generic name: atorvastatin [ a-TOR-va-sta-tin ] Dosage form: oral tablet (10 mg; 20 mg; 40 mg; 80 mg) Drug class: Statins Medically reviewed by Kaci Durbin, MD. In the LUNAR study, while the atorvastatin 80 mg provided a 42% reduction in LDL-C levels, rosuvastatin 40 mg provided a 46.8% reduction in LDL-C levels at the end of 6 weeks (29). thank you so much for your advice take care god bless. Accessibility Head-to-head clinical trials or clinical studies comparing these agents are lacking. The FDA first announced that the 80-mg dose of simvastatin was associated with an increased risk of myopathy and rhabdomyolysis in March 2010, but the agency did not make specific recommendations . This is a process of elimination if nobody can be sure whether her legs' inability to . Fasting blood samples were taken before the randomization within 24 hours and at the end of the 4-week period of the therapy by a cubital venipuncture avoiding venous stasis to an evacuated serum separator tube. It says "If statins are contraindicated or not tolerated: Refer to a specialist with expertise in FH.". Meric M, Soylu K, Avci B, Yuksel S, Gulel O, Yenercag M, et al. Taking atorvastatin oral tablet with other drugs. Endothelial dysfunction, vascular inflammation, atherosclerotic plaque formation, and the rupture of these plaques constitute the basis of the pathophysiology of AMI. Results: Atorvastatin (Oral Route) Side Effects - Mayo Clinic The chi-squared test was used for comparing categorical variables. The present substudy comprised 63 consecutively included patients to examine and compare the effects of atorvastatin 80 mg and rosuvastatin 40 mg on plasma levels of endocan, chemerin, and galectin-3. Had a cholesterol test back in may that came back a 3.1 total (didn't give me the breakdown) but not been offered a liver function test yet, unless they did it at the same time and didn't say. Altunkeser BB, Tuncez A, Ozturk B, Tezcan H, Ates MS, Yilmaz C, et al. and transmitted securely. Had no problems with it. Qiu CR, Fu Q, Sui J, Zhang Q, Wei P, Wu Y, et al. I don't miss the statins at allhoping you feel well very soon.Pat. My husband had 8 stents, and is on 80 atrovastatin plus loads of other tablets for all sorts of things like heart failure, arrhythmia, stroke ICD pacemaker, etc. Almuti K, Rimawi R, Spevack D, Ostfeld RJ. To the best of our knowledge, our investigation is the first study that assessed and compared the effects of high-dose statin therapies on galectin-3 levels in patients with AMI. Case Report: Should anyone still be taking simvastatin 80 mg? I have been told that it could of been worse as my blockage was in the LAD witch is usually called the widow maker. Can I ask what is the benefit you expect to gain from this approach which seems advocated by your GPs - what is the rationale they explain as to why this is necessary.
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